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ACG

h.o.l.M.E.S.

Automated Clinical Guidelines

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PCSK9 Inhibitors
* Prices reflect U.S. average retail price
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Praluent (alirocumab)

Alirocumab (trade name Praluent) is a biopharmaceutical drug approved by the FDA on July 24, 2015, as a second-line treatment for high cholesterol for adults whose cholesterol is not controlled by diet and statin treatment. It is a human monoclonal antibody that belongs to a novel class of anti-cholesterol drugs, known as PCSK9 inhibitors, and it was the first such agent to receive FDA approval.... Wikipedia

 

Manufacturer's Website: Praluent                                                                                                                                                    Average retail cost: $614/2 pens

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Repatha (evolocumab)

Evolocumab (trade name Repatha) is a monoclonal antibody designed for the treatment of hyperlipidemia. Evolocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a protein that targets LDL receptors for degradation and thereby reduces the liver's ability to remove LDL-C, or "bad" cholesterol, from the blood... Wikipedia

 

Manufacturer's Website: Repatha                                                                                                                                               Average retail cost: $334/sureclick

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