ACG
h.o.l.M.E.S.
Automated Clinical Guidelines
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Sirolimus, also known as rapamycin, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection and to treat a rare lung disease called lymphangioleiomyomatosis. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants...Wikipedia
Manufacturer's Website: Rapamune Average retail cost: $900/month
Everolimus is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycin (mTOR). It is currently used as an immunosuppressant to prevent rejection of organ transplants and in the treatment of renal cell cancer and other tumours...Wikipedia
Manufacturer's Website: Not Available Average retail cost: $1,400/month
AFINITOR and AFINITOR DISPERZ™ (everolimus tablets for oral suspension) are prescription medicines used to treat adults and children with a genetic condition called tuberous sclerosis complex (TSC) who have a brain tumor called subependymal giant cell astrocytoma (SEGA) when the tumor cannot be removed completely by surgery.
Manufacturer's Website: Afinitor Average retail cost: $35,669/month
Temsirolimus (codenamed CCI-779) is an intravenous drug for the treatment of renal cell carcinoma (RCC), developed by Wyeth Pharmaceuticals and approved by the U.S. Food and Drug Administration (FDA) in late May 2007...Wikipedia
Manufacturer's Website: Torisel Average retail cost: *
*This drug is administered by your healthcare practitioner, which usually means it may be expensive.
Rapamune (sirolimus)
Zortress (everolimus)
Afinitor/Afinitor Disperz (everolimus)
Torisel (temsirolimus)
mTOR Inhibitors
* Prices reflect U.S. average retail price
