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ACG
​
h.o.l.M.E.S.

Automated Clinical Guidelines

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CFTR Combinations
* Prices reflect U.S. average retail price
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Orkambi (ivacaftor/lumacaftor)

Lumacaftor/ivacaftor (brand name Orkambi) is a combination drug available as a single pill that is used for the treatment of cystic fibrosis in people who have two copies of the F508del mutation in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein... Wikipedia

 

Manufacturer's Website: Orkambi                                                                                                                            Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

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Symdeko (ivacaftor/tezacaftor)

Tezacaftor, also known as VX-661, is a drug approved by the FDA to treat some cases of cystic fibrosis. In 2018, the FDA approved a combination of ivacaftor and tezacaftor; the manufacturer announced a list price of $292,000 per year. The combination of ivacaftor and tezacaftor is being sold as Symdeko... Wikipedia

 

Manufacturer's Website: Symdeko                                                                                                                          Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

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