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ACG
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h.o.l.M.E.S.

Automated Clinical Guidelines

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Antihyperuricemic Agents
* Prices reflect U.S. average retail price
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Zyloprim (allopurinol)

Allopurinol, sold under the brand name Zyloprim among others, is a medication used to decrease high blood uric acid levels. It is specifically used to prevent gout, prevent specific types of kidney stones, and for the high uric acid levels that can occur with chemotherapy. It is taken by mouth or injected into a vein... Wikipedia

 

Manufacturer's Website: Not Available                                                                                                                                         Average retail cost: $188/45 tabs

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Uloric (febuxostat)

Febuxostat, sold under the brand names Uloric and Adenuric, is a medication used in the treatment of chronic gout and hyperuricemia. There are concerns about more heart-related deaths with febuxostat compared to allopurinol. It inhibits xanthine oxidase, thus reducing production of uric acid in the body... Wikipedia

Manufacturer's Website: Uloric                                                                                      Average retail cost: $398/30 tabs

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Elitek (rasburicase)

Rasburicase (trade names Elitek in the US and Fasturtec in Europe) is a medication that helps to clear uric acid from the blood. It is a recombinant version of urate oxidase, an enzyme that metabolizes uric acid to allantoin. Urate oxidase is known to be present in many mammals but does not naturally occur in humans. Rasburicase is produced by a genetically modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain of Aspergillus flavus... Wikipedia

Manufacturer's Website: Elitek                                                                               Average retail cost: $*

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

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Pegloticase (trade name Krystexxa) is a medication for the treatment of severe, treatment-refractory, chronic gout. It is a third-line treatment in those in whom other treatments are not tolerated. The drug is administered by infusion intravenously... Wikipedia

Manufacturer's Website: Krystexxa                                                                                      Average retail cost: *

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Krystexxa (pegloticase)
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