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ACG

h.o.l.M.E.S.

Automated Clinical Guidelines

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Antidiabetic Combinations

Duetact adjunct to diet and exercise in type 2 diabetes in patients already on pioglitazone + a sulfonylurea, or in patients on either pioglitazone or a sulfonylurea who need additional glycemic control.

 

Manufacturer's Website: Not Available                                                                                                                                    Average retail cost: $702/30 tabs

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Duetact (glimepiride/pioglitazone)
* Prices reflect U.S. average retail price

Ertugliflozin (trade name Steglatro) is a drug for the treatment of type 2 diabetes. In the United States, it was approved by the Food and Drug Administration for use as a monotherapy and as a fixed--dose combination with either sitagliptin or with metformin....Wikipedia

 

Manufacturer's Website: Segluromet                                                                                                                                         Average retail cost: $427/60 tabs

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Segluromet (ertugliflozin/metformin)

Pioglitazone/metformin (also known by the brand names Actoplus Met, Piomet and Politor) is combination of two oral diabetes medications pioglitazone and metformin. The two oral antihyperglycemic agents with different mechanisms of action are used to improve glycemic control in patients with diabetes mellitus type 2...Wikipedia

 

Manufacturer's Website: Not Available                                                                                                                                      Average retail cost: $481/30 tabs

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ActoPlus Met XR (metformin/pioglitazone)

DPP-4 inhibitors combined with metformin include a sitagliptin/metformin combination and a saxagliptin combination (Komboglyze), and with alogliptin as Kazano among others...Wikipedia

 

Manufacturer's Website: Kombiglyze                                                                                                                                            Average retail cost: $529/60 tabs

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Kombiglyze XR (metformin/saxagliptin)

In 2013 the FDA approved the drug in three formulations: As a stand-alone with the brand-name Nesina. Combined with metformin using the name Kazano, and when combined with pioglitazone as Oseni... Wikipedia

 

Manufacturer's Website: Not Available                                                                                                                      Average retail cost: $1,5240/180 tabs

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Kazano (alogliptin/metformin)

Sitagliptin/metformin (trade name Janumet) is an anti-diabetic drug, being a combination drug of sitagliptin (a dipeptidyl peptidase-4 inhibitor) and metformin...Wikipedia

 

Manufacturer's Website: Janumet                                                                                                                                                   Average retail cost: $693/60 tabs

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Janumet (metformin/sitagliptin)

Like other medications for the treatment of Type 2 diabetes, alogliptin does not decrease the risk of heart attack and stroke. Like other members of the gliptin class, it causes little or no weight gain, exhibits relatively little risk of causing hypoglycemia, and exhibits relatively modest glucose-lowering activity...Wikipedia

 

Manufacturer's Website: Not Available                                                                                                                                     Average retail cost: $533/30 tabs

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Oseni (alogliptin/pioglitazone)

In Europe, Canada, and elsewhere metformin combined with linagliptin is marketed under the trade name Jentadueto...Wikipedia

 

Manufacturer's Website: Jentadueto                                                                                                                                         Average retail cost: $621/30 tabs

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Jentadueto XR (linagliptin/metformin)

In Europe, Canada, and elsewhere metformin combined with linagliptin is marketed under the trade name Jentadueto...Wikipedia

 

Manufacturer's Website: Jentadueto                                                                                                                    Average retail cost: $621/60 tabs

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Jentadueto (linagliptin/metformin)

In Feb 2017 the FDA approved a once-daily combination of dapagliflozin 10 mg and saxagliptin 5 mg, as Qtern...Wikipedia

 

Manufacturer's Website: Qtern                                                                                                                                                  Average retail cost: $140/6 tabs

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Qtern (dapagliflozin/saxagliptin)

Sitagliptin/metformin (trade name Janumet) is an anti-diabetic drug, being a combination drug of sitagliptin (a dipeptidyl peptidase-4 inhibitor) and metformin...Wikipedia

 

Manufacturer's Website: Janumet                                                                                                                                              Average retail cost: $695/60 tabs

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Janumet XR (metformin/sitagliptin)

Ertugliflozin (trade name Steglatro) is a drug for the treatment of type 2 diabetes. In the United States, it was approved by the Food and Drug Administration for use as a monotherapy and as a fixed dose combination with either sitagliptin or with metformin. A combination with metformin is marketed as Segluromet and a combination with sitagliptin is marketed as Steglujan. ...Wikipedia

 

Manufacturer's Website: Steglujan                                                                                                                                          Average retail cost: $651/30 tabs

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Steglujan (metformin/ertugliflozin)

Dapagliflozin is a drug of the gliflozin class, used to treat type 2 diabetes...Wikipedia

 

Manufacturer's Website: Xigduo                                                                                                                                                    Average retail cost: $690/60 tabs

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Xigduo XR (dapagliflozin/metformin)

Sitagliptin/metformin (trade name Janumet) is an anti-diabetic drug, being a combination drug of sitagliptin (a dipeptidyl peptidase-4 inhibitor) and metformin...Wikipedia

 

Manufacturer's Website: Janumet                                                                                                                                              Average retail cost: $695/60 tabs

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Janumet XR (metformin/sitagliptin)

Ertugliflozin (trade name Steglatro) is a drug for the treatment of type 2 diabetes. In the United States, it was approved by the Food and Drug Administration for use as a monotherapy and as a fixed dose combination with either sitagliptin or with metformin. A combination with metformin is marketed as Segluromet and a combination with sitagliptin is marketed as Steglujan. ...Wikipedia

 

Manufacturer's Website: Steglujan                                                                                                                                          Average retail cost: $651/30 tabs

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Steglujan (metformin/ertugliflozin)

Dapagliflozin is a drug of the gliflozin class, used to treat type 2 diabetes...Wikipedia

 

Manufacturer's Website: Xigduo                                                                                                                                                    Average retail cost: $690/60 tabs

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Xigduo XR (dapagliflozin/metformin)

Synjardy (empagliflozin and metformin) is used to lower blood sugar and treat type 2 diabetes.

 

Manufacturer's Website: Synjardy                                                                                                                                                        Average retail cost: $768/60 tabs

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Synjardy XR (empagliflozin/metformin)

Canagliflozin (trade name Invokana or Sulisent) is a medication used for the treatment of type 2 diabetes. It is of the gliflozin class or subtype 2 sodium-glucose transport (SGLT-2) inhibitors class...Wikipedia

 

Manufacturer's Website: Invokamet                                                                                                                                              Average retail cost: $708/60 tabs

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Invokamet (canagliflozin/metformin)

Empagliflozin/linagliptin is a drug combination used for the treatment of type II diabetes. It is a combination of empagliflozin and linagliptin. The combination preparation was developed and is marketed by Boehringer Ingelheim and Eli Lilly under the trade name Glyxambi...Wikipedia

 

Manufacturer's Website: Glyxambi                                                                                                                                                 Average retail cost: $723/30 tabs

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Glyxambi (empagliflozin/linagliptin)

Pioglitazone/metformin (also known by the brand names Actoplus Met, Piomet and Politor) is combination of two oral diabetes medications pioglitazone and metformin. The two oral antihyperglycemic agents with different mechanisms of action are used to improve glycemic control in patients with diabetes mellitus type 2...Wikipedia

 

Manufacturer's Website: Not Available                                                                                                                                       Average retail cost: $636/60 tablets

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ActoPlus Met (metformin/pioglitazone)

Insulin glargine/lixisenatide is a combination drug that combines insulin glargine and lixisenatide and is used as second-line treatment for diabetes...Wikipedia

 

Manufacturer's Website: Soliqua                                                                                                                                       Average retail cost: $1,052/carton

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Soliqua (insulin glargine/lixisenatide)

Insulin glargine/lixisenatide is a combination drug that combines insulin glargine and lixisenatide and is used as second-line treatment for diabetes...Wikipedia

 

Manufacturer's Website: Xultophy                                                                                                                                             Average retail cost: $1,529/5 pens

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Xultophy (insulin degludec/liraglutide)

Empagliflozin/linagliptin/metformin, sold under the brand name Trijardy XR, is a drug combination used for the treatment of type 2 diabetes. It is a combination of empagliflozin, linagliptin, and metformin. Empagliflozin/linagliptin/metformin was approved for use in the United States in January 2020....Wikipedia

 

Manufacturer's Website: TrijardyXR                                                                                                                                              Average retail cost: $723/60 tabs

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Trijardy XR (Empagliflozin/linagliptin/metformin)

Synjardy (empagliflozin and metformin) is used to lower blood sugar and treat type 2 diabetes.

 

Manufacturer's Website: Synjardy                                                                                                                                                      Average retail cost: $364/30 tabs

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Synjardy (empagliflozin/metformin)

Canagliflozin (trade name Invokana or Sulisent) is a medication used for the treatment of type 2 diabetes. It is of the gliflozin class or subtype 2 sodium-glucose transport (SGLT-2) inhibitors class...Wikipedia

 

Manufacturer's Website: Invokamet                                                                                                                                              Average retail cost: $708/60 tabs

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Invokamet XR (canagliflozin/metformin)
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